Surgical stress and cancer progression: the twisted tango

Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection potentially enhances metastatic seeding of tumor cells. In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. We also propose preventive strategies or resolution of tumor metastasis caused by surgical stress.

Frontiers Laparoscopic Versus Open Surgery for Early-Stage

Cancers, Free Full-Text

Frontiers Perioperative Inflammatory Response and Cancer

Full article: Surgical Trauma-induced CCL2 Upregulation Mediates

Repurposing antidepressant sertraline as a pharmacological drug to

New insights into the correlations between circulating tumor cells

Perioperative factors associated with survival following surgery

Tumor regionalization after surgery: Roles of the tumor

Micellar nanoparticles inhibit the postoperative inflammation

New insights into the correlations between circulating tumor cells

JMP, Free Full-Text

JCM, Free Full-Text

The role of necroptosis in cancer biology and therapy

Frontiers RIG-1-Like Receptor Activation Synergizes With

Pathology of circulating tumor cells and the available capture

Essential thrombocythaemia (ET)

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