Cancers, Free Full-Text
5 (770) In stock
Until recently, despite its heterogenous biology, metastatic triple negative breast cancer (TNBC) was treated as a single entity, with successive lines of palliative chemotherapy being the only systemic option. Significant gene expression studies have demonstrated the diversity of TNBC, but effective differential targeting of the four main (Basal-like 1 and 2, mesenchymal and luminal androgen receptor) molecular sub-types has largely eluded researchers. The introduction of immunotherapy, currently useful only for patients with PD-L1 positive cancers, led to the stratification of first-line therapy using this immunohistochemical biomarker. Germline BRCA gene mutations can also be targeted with PARP inhibitors in both the adjuvant and metastatic settings. In contrast, the benefit of the anti-Trop-2 antibody-drug conjugate (ADC) Sacituzumab govitecan (SG) does not appear confined to patients with tumours expressing high levels of Trop-2, leading to its potential utility for any patient with an estrogen receptor (ER)-negative, HER2-negative advanced breast cancer (ABC). Most recently, low levels of HER2 expression, detected in up to 60% of TNBC, predicts benefit from the potent HER2-directed antibody-drug conjugate trastuzumab deruxtecan (T-DXd), defining an additional treatment option for this sub-group. Regrettably, despite recent advances, the median survival of TNBC continues to lag far behind the approximately 5 years now expected for patients with ER-positive or HER2-positive breast cancers. We review the data supporting immunotherapy, ADCs, and targeted agents in subgroups of patients with TNBC, and current clinical trials that may pave the way to further advances in this challenging disease.
ACF not offering free surgeries to breast cancer patients - FactCheckZW
Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer
Cancers, Free Full-Text
Cancers, Free Full-Text
Cancers, Free Full-Text
Evans Syndrome In Dogs Survival Rate Deals
Cancers, Free Full-Text, papa's burgeria poki
13 Ways to Text a Cancer - wikiHow
Free Cure-All Blood Cancer Drug in Pune? Don't Fall For This Old Fake Message - Fact Crescendo
Cancers, Free Full-Text, clube aurora ao vivo
Breast Reduction- Patient 136 Jonathan Hall, MD, FACSJonathan Hall, MD, FACS
Amy hero explaining why a 15 year old having triple D tits is integral to the plot II - iFunny
Do You Need a Breast Lift with Your Augmentation? - The Plastic Surgery Channel
Trans femboy:D (I have triple d tits and it was so hard to hide for this) : r/teenfemboy
Kerry Katona shows new boobs in low cut jumpsuit after surgery - Daily Star
- J.Jill - Introducing Pure Jill Tranquility fleece, our ultrasoft brushed fabric with four-way stretch. Fall never felt so good. Shop now
- Bling Shapers Colombian Butt Lifting Shapewear For Women Open Bust Faja Colombiana Mujer Postpartum Body Shaper size L Color Khaki
- Empetua™ High-Waisted shaper shorts
- Yoga Short Eco Friendly with Side-Tie
- Pull-Ups New Leaf Girls' Disney Frozen Potty Training Pants - 3T-4T - Shop Training Pants at H-E-B
- Mackenzie Dern plans 'to correct the mistakes' after UFC 298 loss